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Long Term Side Effects of Tramadol?

Side Effects of tramadol

Are you on Tramadol now for pain relief? While this medication can be effective in managing moderate to severe pain, it can also cause moderate to serious side effects. From physical symptoms like nausea and dizziness to more serious issues like addiction and respiratory depression, these side effects can hamper your daily routine. In this regard, let’s explore all possible side effects of Tramadol and know how to avoid them with ease. But before we dive deeper, let’s understand the drug a bit clearly!

Tramadol overview

Tramadol is an effective analgesic used for pain management due to its unique working mechanism. This drug binds to the opioid receptors in the brain and subsequently blocks off nerve pathways that carry the pain sensation, thus providing relief. Tramadol also works on monoamine neurotransmitters to extend its effectiveness in being a potent pain reliever. However, it can be habit-forming. Hence, you should use it as per the prescribed dosage and frequency. While it is generally safe and effective, there are some potential side effects with its use. If you experience any of the side effects we are going to discuss below, be sure to tell your doctor right away.

Let’s talk about Some Common side effects.

Common Side Effects

These side effects of Tramadol are generally less serious and may go away on their own as the body adjusts to the medication. However, some people still feel uncomfortable as these side effects may interfere with daily activities.

Here are some examples of common side effects:

1. Nausea and vomiting – Tramadol can cause feelings of nausea and may even cause vomiting in some people. Taking the medication with food or reducing the dose may help alleviate these symptoms.

2. Dizziness – The drug can make you feel dizzy or lightheaded. This could be dangerous for people operating heavy machinery or driving.

3. Headache – Headaches are common after taking Tramadol. Drinking plenty of water and taking over-the-counter pain relievers may help alleviate the pain with ease.

4. Constipation – Some people feel slow digestion which is followed by constipation. Drinking plenty of water and eating high-fibre foods during the course could help.

5. Sweating – You may feel excessive sweating at night. Doctors may advise you to wear loose clothes or to be inside an air-conditioned room, if possible.

6. Dry mouth – Tramadol can cause a dry mouth, which can lead to bad breath and other oral health issues. Drinking plenty of water and using sugar-free gum or candy can help alleviate dry mouth.

Interestingly, not everyone will experience these side effects, and some people may experience different or more severe side effects. If you experience any concerning symptoms while taking Tramadol, you should contact your healthcare provider.

Serious Side Effects

Now, let’s talk about some serious side effects.

1. Seizures – Tramadol can lower the seizure threshold and thus may increase the risk of seizures in some people. The chances are high when you are either overdosing or have a history of seizures.

2. Serotonin syndrome – The drug is capable of increasing serotonin levels in your brain, which can lead to a rare but potentially life-threatening condition called serotonin syndrome. As a result, you may experience confusion, rapid heart rate, high blood pressure, fever, sweating, and muscle rigidity.

3. Respiratory depression – Tramadol can slow down breathing and lead to respiratory depression. This is less likely to occur if you’re not overdosing, do not have any respiratory issues, or not combining Tramadol with other medications that can cause respiratory depression.

4. Hypotension – Tramadol can cause low blood pressure, which can cause dizziness or fainting. Again, the probabilities are high if you are overdosing or combining the drug with medications that lower blood pressure.

5. Cardiac arrest – You should be very careful with Tramadol increase if you already have any underlying heart conditions. The medication can definitely increase the risk of cardiac arrest without a doctor’s supervision.

Risk Factors for Side Effects

Now let’s understand some of the risk factors that may increase the likelihood of experiencing side effects from Tramadol use.

  • Age – Old patients are more susceptible to bad side effects from Tramadol due to changes in metabolism and overall health.
  • Genetics – Some people may have genetic variations that affect how they metabolize Tramadol, which can increase the risk of side effects.
  • Medical history – If you have any liver or kidney disease, you may be more susceptible to side effects because of the drug’s complex metabolization in the body.
  • Interactions with other drugs – Tramadol can interact with other medications such as antidepressants, antihistamines, and opioids, leading to unwanted side effects.
  • Dosage – Frequent drug overdose can amplify the risk of side effects. If you have conditions such as seizures and respiratory depression, you should be more careful.

It’s important to discuss any risk factors with your healthcare provider before taking Tramadol. They can help you determine whether Tramadol is the best treatment option for you and monitor you for potential side effects. In some cases, they may recommend a lower dose or an alternative medication to reduce the risk of side effects.


Tramadol is highly effective, but like all medications, it can also come with certain side effects. Most commonly, you may experience nausea, dizziness and constipation. More severe side effects could include liver damage and serotonin syndrome. But not everyone will experience these negative side effects. However, to be on the safe side, consult your doctor immediately if you feel any uneasiness after taking Tramadol.

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